Gene therapy in diabetes: A review of case study conducted over mice to cure type 2 diabetes and obesity

Abstract

Type 1 diabetes “(T1D) is characterized by the destruction of insulin-secreting beta cells in the pancreas, which results in insulin insufficiency and hyperglycemia. If they don't have daily insulin injections, these patients will die from diabetic ketoacidosis (DKA). T1D patients may benefit from a variety of gene therapy techniques, including viral vector and non-viral transduction, such as decreasing autoreactive T cells to minimize islet death (prophylactic) or substituting the insulin gene for patients (post-disease). The lack of cadaveric islets for transplantation and the associated immunosuppression necessitated the development of a novel strategy for attaining euglycemia. Despite extensive research on insulin ectopic expression and islet modification, no cure has yet to be discovered. In the treatment of Type 1 Diabetes (T1D)”, numerous gene transfer techniques and a range of gene therapy procedures have been used, as well as possible novel treatments.